[HTML][HTML] Free cholesterol loading of macrophages induces apoptosis involving the fas pathway

PM Yao, I Tabas - Journal of Biological Chemistry, 2000 - ASBMB
Macrophage death is an important feature of atherosclerosis, but the cellular mechanism for
this process is largely unknown. There is increasing interest in cellular free cholesterol (FC)
excess as an inducer of lesional macrophage death because macrophages accumulate
large amounts of FC in vivo, and FC loading of macrophages in culture causes cell death. In
this study, a cell culture model was used to explore the cellular mechanisms involved in the
initial stages of FC-induced macrophage death. After 9 h of FC loading, some of the …