[HTML][HTML] Poly (ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase …
Robust activation of poly (ADP-ribose) polymerase-1 (PARP) by oxidative stress has been
implicated as a major cause of caspase-independent myocyte cell death contributing to
heart failure. Here, we show that depletion of myocyte NAD levels and the subsequent
reduction of Sir2α deacetylase activity are the sequential steps contributing to PARP-
mediated myocyte cell death. In both failing hearts and cultured cardiac myocytes, the
increased activity of PARP was associated with depletion of cellular NAD levels and …
implicated as a major cause of caspase-independent myocyte cell death contributing to
heart failure. Here, we show that depletion of myocyte NAD levels and the subsequent
reduction of Sir2α deacetylase activity are the sequential steps contributing to PARP-
mediated myocyte cell death. In both failing hearts and cultured cardiac myocytes, the
increased activity of PARP was associated with depletion of cellular NAD levels and …