The forkhead transcription factor Foxo3a is able to inhibit cardiomyocyte hypertrophy.
However, its underlying molecular mechanism remains to be fully understood. Our present
study demonstrates that Foxo3a can regulate cardiomyocyte hypertrophy through
transactivating catalase. Insulin was able to induce cardiomyocyte hypertrophy with an
elevated level of reactive oxygen species (ROS). The antioxidant agents, including catalase
and N-acetyl-l-cysteine, could inhibit cardiomyocyte hypertrophy induced by insulin …