Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists
PH Sugden, A Clerk - Trends in cardiovascular medicine, 2000 - Elsevier
The small (21-kDa) guanine nucleotide-binding protein Ras plays a central role in the
regulation of cell growth and division. In the cardiac myocyte, it has been implicated in the
hypertrophic adaptation. We have recently examined the ability of hypertrophic agonists
such as endothelin-1, phenylephrine and phorbol esters to increase the “activity”(GTP
loading) of Ras. We have also studied the signaling events that lead to activation of Ras and
the processes that respond to Ras activation. In this brief review, we describe these studies …
regulation of cell growth and division. In the cardiac myocyte, it has been implicated in the
hypertrophic adaptation. We have recently examined the ability of hypertrophic agonists
such as endothelin-1, phenylephrine and phorbol esters to increase the “activity”(GTP
loading) of Ras. We have also studied the signaling events that lead to activation of Ras and
the processes that respond to Ras activation. In this brief review, we describe these studies …