Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells.
KK Griendling, P Delafontaine, SE Rittenhouse… - Journal of Biological …, 1987 - ASBMB
Angiotensin II stimulates sequential phospholipase C-mediated hydrolysis of initially the
polyphosphoinositides and subsequently phosphatidylinositol (PI) in cultured rat aortic
smooth muscle cells resulting in biphasic, sustained formation of diacylglycerol (DG). The
mechanisms underlying this delayed induction of sustained DG accumulation are unknown
but may be related to cellular events including processing of the angiotensin II receptor-
ligand complex. In the present study, we characterized the kinetics of angiotensin II receptor …
polyphosphoinositides and subsequently phosphatidylinositol (PI) in cultured rat aortic
smooth muscle cells resulting in biphasic, sustained formation of diacylglycerol (DG). The
mechanisms underlying this delayed induction of sustained DG accumulation are unknown
but may be related to cellular events including processing of the angiotensin II receptor-
ligand complex. In the present study, we characterized the kinetics of angiotensin II receptor …