[HTML][HTML] Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade
SE Woodman, DS Park, AW Cohen… - Journal of Biological …, 2002 - ASBMB
A growing body of evidence suggests that muscle cell caveolae may function as specialized
membrane micro-domains in which the dystrophin-glycoprotein complex and cellular
signaling molecules reside. Caveolin-3 (Cav-3) is the only caveolin family member
expressed in striated muscle cell types (cardiac and skeletal). Interestingly, skeletal muscle
fibers from Cav-3 (−/−) knock-out mice show a number of myopathic changes, consistent
with a mild-to-moderate muscular dystrophy phenotype. However, it remains unknown …
membrane micro-domains in which the dystrophin-glycoprotein complex and cellular
signaling molecules reside. Caveolin-3 (Cav-3) is the only caveolin family member
expressed in striated muscle cell types (cardiac and skeletal). Interestingly, skeletal muscle
fibers from Cav-3 (−/−) knock-out mice show a number of myopathic changes, consistent
with a mild-to-moderate muscular dystrophy phenotype. However, it remains unknown …