Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical …
SY Flores, D Loffing-Cueni, E Kamynina… - Journal of the …, 2005 - journals.lww.com
Aldosterone plays a central role in Na+ homeostasis by controlling Na+ reabsorption in the
aldosterone-sensitive distal nephron involving the epithelial Na+ channel (ENaC). Part of
the effects of aldosterone is mediated by serum and glucocorticoid-induced kinase 1 (Sgk1),
a Ser/Thr kinase whose expression is rapidly induced by aldosterone and that increases in
heterologous expression systems ENaC cell surface abundance and activity. Previous work
in Xenopus laevis oocytes suggested that Sgk1 phosphorylates specific residues (Ser212 …
aldosterone-sensitive distal nephron involving the epithelial Na+ channel (ENaC). Part of
the effects of aldosterone is mediated by serum and glucocorticoid-induced kinase 1 (Sgk1),
a Ser/Thr kinase whose expression is rapidly induced by aldosterone and that increases in
heterologous expression systems ENaC cell surface abundance and activity. Previous work
in Xenopus laevis oocytes suggested that Sgk1 phosphorylates specific residues (Ser212 …