Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG …
AM Krieg, SM Efler, M Wittpoth… - Journal of …, 2004 - journals.lww.com
Subcutaneous injection of normal human volunteers with a B-class CpG
oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH 1-like pattern of
systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-α, and
IFN-inducible chemokines. Serum IP-10 was found to be the most sensitive assay for
subcutaneous CPG 7909 stimulation; its level was significantly increased in all subjects at
all dose levels, including the lowest tested dose of just 0.0025 mg/kg. This pattern of …
oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH 1-like pattern of
systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-α, and
IFN-inducible chemokines. Serum IP-10 was found to be the most sensitive assay for
subcutaneous CPG 7909 stimulation; its level was significantly increased in all subjects at
all dose levels, including the lowest tested dose of just 0.0025 mg/kg. This pattern of …