Modelling breast cancer: one size does not fit all
T Vargo-Gogola, JM Rosen - Nature Reviews Cancer, 2007 - nature.com
Nature Reviews Cancer, 2007•nature.com
Breast cancer is not a single disease, but is instead a collection of diseases that have
distinct histopathological features, genetic and genomic variability, and diverse prognostic
outcomes. Thus, no individual model would be expected to completely recapitulate this
complex disease. Here, the models commonly used to investigate breast cancer including
cell lines, xenografts and genetically engineered mice, are discussed to help address the
question: what is the most powerful way to investigate this heterogeneous disease?
distinct histopathological features, genetic and genomic variability, and diverse prognostic
outcomes. Thus, no individual model would be expected to completely recapitulate this
complex disease. Here, the models commonly used to investigate breast cancer including
cell lines, xenografts and genetically engineered mice, are discussed to help address the
question: what is the most powerful way to investigate this heterogeneous disease?
Abstract
Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. Thus, no individual model would be expected to completely recapitulate this complex disease. Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?
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