Multiple studies suggest that lipid oversupply to skeletal muscle contributes to the
development of insulin resistance, perhaps by promoting the accumulation of lipid
metabolites capable of inhibiting signal transduction. Herein we demonstrate that exposing
muscle cells to particular saturated free fatty acids (FFAs), but not mono-unsaturated FFAs,
inhibits insulin stimulation of Akt/protein kinase B, a serine/threonine kinase that is a central
mediator of insulin-stimulated anabolic metabolism. These saturated FFAs concomitantly …