[HTML][HTML] A controlled high-fat diet induces an obese syndrome in rats
The prevalence of obesity is increasing. Although the etiology of obesity is complex, dietary
factors, particularly the consumption of a high-fat (HF) diet, is considered a risk factor for its
development. Nonetheless, a causal role of dietary fat has never been definitively
documented, in part because of inadequate animal models. We developed a rat model of
diet-induced obesity that will be a powerful tool for assessment of this issue. In four
experiments, Long-Evans rats ate ad libitum a synthetic semipurified diet containing 20 g …
factors, particularly the consumption of a high-fat (HF) diet, is considered a risk factor for its
development. Nonetheless, a causal role of dietary fat has never been definitively
documented, in part because of inadequate animal models. We developed a rat model of
diet-induced obesity that will be a powerful tool for assessment of this issue. In four
experiments, Long-Evans rats ate ad libitum a synthetic semipurified diet containing 20 g …