Pharmacokinetics of hydroxyurea in nude mice
CL Van Den Berg, JR McGill, JG Kuhn… - Anti-Cancer …, 1994 - journals.lww.com
Extrachromosomal DNA is the predominant form of gene amplification In human tumors.
Hydroxyurea (HU) concentrations of 100-150 IAM have been promising In vitro for
extrachromosomal DNA elimination. The study objective was to determine the HU dose-
concentration relationship in nude mice with HU doses from 0 to 200 mg/kg. For HU t1/2
determination, mice were Injected with HU 100 mg/kg. A plasma concentration of 159 pM
was achieved and a t1/2 of 11.3 mln determined. Based on these findings, In vivo …
Hydroxyurea (HU) concentrations of 100-150 IAM have been promising In vitro for
extrachromosomal DNA elimination. The study objective was to determine the HU dose-
concentration relationship in nude mice with HU doses from 0 to 200 mg/kg. For HU t1/2
determination, mice were Injected with HU 100 mg/kg. A plasma concentration of 159 pM
was achieved and a t1/2 of 11.3 mln determined. Based on these findings, In vivo …