[HTML][HTML] Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
BB Madison, L Dunbar, XT Qiao, K Braunstein… - Journal of Biological …, 2002 - ASBMB
Villin, an actin bundling protein found in the apical brush border of absorptive tissues, is one
of the first structural genes to be transcriptionally activated in the embryonic intestinal
endoderm. In the adult, villin is broadly expressed in every cell of the intestinal epithelium on
both the vertical axis (crypt to villus tip) and the horizontal axis (duodenum through colon) of
the intestine. Here, we document that a 12.4-kilobase region of the mouse villin gene drives
high level expression of two different reporter genes (LacZ and Cre recombinase) within the …
of the first structural genes to be transcriptionally activated in the embryonic intestinal
endoderm. In the adult, villin is broadly expressed in every cell of the intestinal epithelium on
both the vertical axis (crypt to villus tip) and the horizontal axis (duodenum through colon) of
the intestine. Here, we document that a 12.4-kilobase region of the mouse villin gene drives
high level expression of two different reporter genes (LacZ and Cre recombinase) within the …