[HTML][HTML] Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
P Sharma, M Sharma, ND Amin, RK Sihag… - Journal of Biological …, 2002 - ASBMB
Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in
postmitotic cells and plays important roles in neuronal development and migration, neurite
outgrowth, and synaptic transmission. In this study we investigated the relationship between
cdk5 activity and regulation of the mitogen-activated protein (MAP) kinase pathway. We
report that cdk5 phosphorylates the MAP kinase kinase-1 (MEK1) in vivo as well as the Ras-
activated MEK1 in vitro. The phosphorylation of MEK1 by cdk5 resulted in inhibition of MEK1 …
postmitotic cells and plays important roles in neuronal development and migration, neurite
outgrowth, and synaptic transmission. In this study we investigated the relationship between
cdk5 activity and regulation of the mitogen-activated protein (MAP) kinase pathway. We
report that cdk5 phosphorylates the MAP kinase kinase-1 (MEK1) in vivo as well as the Ras-
activated MEK1 in vitro. The phosphorylation of MEK1 by cdk5 resulted in inhibition of MEK1 …