Evidence for autoimmune antibodies directed against embryonic neural cell adhesion molecules (N-CAM) in patients with group B meningitis
J Nedelec, J Bourcraut, JM Garnier… - Journal of …, 1990 - Elsevier
Human brain tissue shares α2–8 linked polymers of neuraminic acid with the carbohydrates
expressed on the capsule of group B Neisseria mengitidis bacteria (Finne et al.(1983)
Lancet ii, 355–357; Finne (1985) Trends Biochem. Sci. 10, 129–132; Rougon et al.(1986) J.
Cell. Biol. 103, 2429–2437). We report that sera from patients suffering from group B
meningitis exhibited IgM antibodies directed against the embryonic, but not the adult, form of
neural cell adhesion molecules (N-CAM). These sera also stained live ATt20 cells as well as …
expressed on the capsule of group B Neisseria mengitidis bacteria (Finne et al.(1983)
Lancet ii, 355–357; Finne (1985) Trends Biochem. Sci. 10, 129–132; Rougon et al.(1986) J.
Cell. Biol. 103, 2429–2437). We report that sera from patients suffering from group B
meningitis exhibited IgM antibodies directed against the embryonic, but not the adult, form of
neural cell adhesion molecules (N-CAM). These sera also stained live ATt20 cells as well as …