Antitoxin vaccines and pathogen virulence
B Soubeyrand, SA Plotkin - Nature, 2002 - nature.com
B Soubeyrand, SA Plotkin
Nature, 2002•nature.comIn their mathematical description of vaccine-induced immunity, Gandon et al. predict that the
host's immunity to a microbial toxin will lead to increased virulence of the pathogen without
affecting its transmission. However, results obtained using vaccines against two additional
bacterial pathogens are not consistent with this prediction. The model proposed by Gandon
et al. may therefore be an oversimplification, with the outcome depending on the biological
details of both the pathogen and the vaccine.
host's immunity to a microbial toxin will lead to increased virulence of the pathogen without
affecting its transmission. However, results obtained using vaccines against two additional
bacterial pathogens are not consistent with this prediction. The model proposed by Gandon
et al. may therefore be an oversimplification, with the outcome depending on the biological
details of both the pathogen and the vaccine.
Abstract
In their mathematical description of vaccine-induced immunity, Gandon et al. predict that the host's immunity to a microbial toxin will lead to increased virulence of the pathogen without affecting its transmission. However, results obtained using vaccines against two additional bacterial pathogens are not consistent with this prediction. The model proposed by Gandon et al. may therefore be an oversimplification, with the outcome depending on the biological details of both the pathogen and the vaccine.
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