Reaction of rabbit leucocytes to staphylococcal (Panton-Valentine) leucocidin in vivo.
S Szmigielski, J Jeljaszewicz, J Wilczynski… - Journal of Pathology …, 1966 - cabdirect.org
S Szmigielski, J Jeljaszewicz, J Wilczynski, M Korbecki
Journal of Pathology and Bacteriology, 1966•cabdirect.orgIn these experiments the intravenous injection in rabbits of highly purified leucocidin caused
changes in the metabolism of leukocytes, variations in the numbers present in the peripheral
blood and a granulopoietic reaction in the bone marrow. All these changes could be
demonstrated by the injection of 1 mgm. per kgm. body weight, a dose which was otherwise
well tolerated by the rabbits. After the injection there was during the first 4 hours a rapid fall
in the numbers of polymorph leukocytes in the peripheral blood and bone marrow and of …
changes in the metabolism of leukocytes, variations in the numbers present in the peripheral
blood and a granulopoietic reaction in the bone marrow. All these changes could be
demonstrated by the injection of 1 mgm. per kgm. body weight, a dose which was otherwise
well tolerated by the rabbits. After the injection there was during the first 4 hours a rapid fall
in the numbers of polymorph leukocytes in the peripheral blood and bone marrow and of …
Abstract
In these experiments the intravenous injection in rabbits of highly purified leucocidin caused changes in the metabolism of leukocytes, variations in the numbers present in the peripheral blood and a granulopoietic reaction in the bone marrow. All these changes could be demonstrated by the injection of 1 mgm. per kgm. body weight, a dose which was otherwise well tolerated by the rabbits.
After the injection there was during the first 4 hours a rapid fall in the numbers of polymorph leukocytes in the peripheral blood and bone marrow and of lymphocytes in the blood. Between 12 and 24 hours after injection however, the number of circulating polymorphs increased rapidly and this was accompanied in the marrow by increases in the proportion of young myeloid cells and in the mitotic index.
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