Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

AC Wotherspoon, C Ortiz-Hidalgo, MR Falzon… - The Lancet, 1991 - Elsevier
AC Wotherspoon, C Ortiz-Hidalgo, MR Falzon, PG Isaacson
The Lancet, 1991Elsevier
Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in
the stomach and most of these recapitulate the features of mucosa-associated lymphoid
tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection
by Helicobacter pylori, and we have confirmed this in 450 patients with H pylori-associated
gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes
infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases …
Abstract
Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori,and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pyloriinfection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.
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