[HTML][HTML] Determinants of non-toxicity in the gastric pathogen Helicobacter pylori
DP Letley, JL Rhead, RJ Twells, B Dove… - Journal of Biological …, 2003 - ASBMB
The Helicobacter pylori vacuolating cytotoxin gene, vacA, is naturally polymorphic, the two
most diverse regions being the signal region (which can be type s1 or s2) and the mid
region (m1 or m2). Previous work has shown which features of vacA make peptic ulcer and
gastric cancer-associated type s1/m1 and s1/m2 strains toxic. vacA s2/m2 strains are
associated with lower peptic ulcer and gastric cancer risk and are non-toxic. We now define
the features of vacA that determine the non-toxicity of these strains. To do this, we deleted …
most diverse regions being the signal region (which can be type s1 or s2) and the mid
region (m1 or m2). Previous work has shown which features of vacA make peptic ulcer and
gastric cancer-associated type s1/m1 and s1/m2 strains toxic. vacA s2/m2 strains are
associated with lower peptic ulcer and gastric cancer risk and are non-toxic. We now define
the features of vacA that determine the non-toxicity of these strains. To do this, we deleted …