Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial

BCY Wong, SK Lam, WM Wong, JS Chen, TT Zheng… - Jama, 2004 - jamanetwork.com
ContextAlthough chronic Helicobacter pylori infection is associated with gastric cancer, the
effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is
unknown. ObjectiveTo determine whether treatment of H pylori infection reduces the
incidence of gastric cancer. Design, Setting, and ParticipantsProspective, randomized,
placebo-controlled, population-based primary prevention study of 1630 healthy carriers of H
pylori infection from Fujian Province, China, recruited in July 1994 and followed up until …