Is Helicobacter pylori seropositivity related to body mass index in the United States?
GN Ioannou, NS Weiss… - Alimentary pharmacology …, 2005 - Wiley Online Library
GN Ioannou, NS Weiss, DJ Kearney
Alimentary pharmacology & therapeutics, 2005•Wiley Online LibraryBackground: Helicobacter pylori infection may decrease serum ghrelin and increase gastric
leptin levels, which may, in turn, decrease body mass index. Aim: To determine whether H.
pylori seropositivity is associated with body mass index. Methods: Serum H. pylori and
cytotoxin‐associated gene product A (CagA) antibody levels were measured on 6724 adult
participants of the third National Health and Nutrition Examination Survey (1988–91). We
evaluated the association between H. pylori/CagA antibody status [both negative (−/−), H …
leptin levels, which may, in turn, decrease body mass index. Aim: To determine whether H.
pylori seropositivity is associated with body mass index. Methods: Serum H. pylori and
cytotoxin‐associated gene product A (CagA) antibody levels were measured on 6724 adult
participants of the third National Health and Nutrition Examination Survey (1988–91). We
evaluated the association between H. pylori/CagA antibody status [both negative (−/−), H …
Summary
Background: Helicobacter pylori infection may decrease serum ghrelin and increase gastric leptin levels, which may, in turn, decrease body mass index.
Aim: To determine whether H. pylori seropositivity is associated with body mass index.
Methods: Serum H. pylori and cytotoxin‐associated gene product A (CagA) antibody levels were measured on 6724 adult participants of the third National Health and Nutrition Examination Survey (1988–91). We evaluated the association between H. pylori/CagA antibody status [both negative (−/−), H. pylori‐positive/CagA‐negative (+/−), or both positive (+/+)] and body mass index, adjusting for sociodemographic factors. We also investigated whether H. pylori/cytotoxin‐associated gene product A antibody status was associated with fasting serum leptin levels.
Results: H. pylori/CagA antibody status was not associated with obesity (body mass index ≥ 30 kg/m2) [adjusted odds ratio (OR) 1.2, 95% CI: 0.9–1.6 comparing (+/+) to (−/−) and adjusted OR 1.1, 95% CI: 0.8–1.5 comparing (+/−) to (−/−)], overweight (body mass index 25 to <30 kg/m2) [adjusted OR 1.0, 95% CI: 0.7–1.2 comparing (+/+) to (−/−) and adjusted OR 1.0, 95% CI: 0.8–1.3 comparing (+/−) to (−/−)], or fasting serum leptin level in the USA population.
Conclusions: H. pylori seropositivity and CagA antibody status are not associated with body mass index or fasting serum leptin level.
Wiley Online Library