[HTML][HTML] Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors …
G Krishnegowda, AM Hajjar, J Zhu, EJ Douglass… - Journal of Biological …, 2005 - ASBMB
The glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum have been
proposed to be the major factors that contribute to malaria pathogenesis through their ability
to induce proinflammatory responses. In this study we identified the receptors for P.
falciparum GPI-induced cell signaling that leads to proinflammatory responses and studied
the GPI structure-activity relationship. The data show that GPI signaling is mediated mainly
through recognition by TLR2 and to a lesser extent by TLR4. The activity of sn-2-lyso-GPIs is …
proposed to be the major factors that contribute to malaria pathogenesis through their ability
to induce proinflammatory responses. In this study we identified the receptors for P.
falciparum GPI-induced cell signaling that leads to proinflammatory responses and studied
the GPI structure-activity relationship. The data show that GPI signaling is mediated mainly
through recognition by TLR2 and to a lesser extent by TLR4. The activity of sn-2-lyso-GPIs is …