Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

AC Newton - Biochemical Journal, 2003 - portlandpress.com
Biochemical Journal, 2003portlandpress.com
Phosphorylation plays a central role in regulating the activation and signalling lifetime of
protein kinases A, B (also known as Akt) and C. These kinases share three conserved
phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic
motif. This review focuses on how phosphorylation at each of these sites regulates the
maturation, signalling and down-regulation of PKC as a paradigm for how these sites control
the function of the ABC kinases.
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.
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