[HTML][HTML] Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities

B Razani, TP Combs, XB Wang, PG Frank… - Journal of Biological …, 2002 - ASBMB
Caveolae organelles and caveolin-1 protein expression are most abundant in adipocytes
and endothelial cells. Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a
loss of caveolae and perturbations in endothelial cell function. More recently, however,
observation of the Cav-1-deficient cohorts into old age revealed significantly lower body
weights, as compared with wild-type controls. These results suggest that Cav-1 null mice
may have problems with lipid metabolism and/or adipocyte functioning. To test this …