Neonatal tolerance revisited: turning on newborn T cells with dendritic cells
JP Ridge, EJ Fuchs, P Matzinger - Science, 1996 - science.org
JP Ridge, EJ Fuchs, P Matzinger
Science, 1996•science.orgFor some time it has been thought that antigenic challenge in neonatal life is a tolerogenic
rather than immunogenic event. Reexamination of the classic neonatal tolerance
experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic
property of the newborn immune system, but that the nature of the antigen-presenting cell
determines whether the outcome is neonatal tolerance or immunization.
rather than immunogenic event. Reexamination of the classic neonatal tolerance
experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic
property of the newborn immune system, but that the nature of the antigen-presenting cell
determines whether the outcome is neonatal tolerance or immunization.
For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
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