Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia

CL Mack, RM Tucker, RJ Sokol, BL Kotzin - Clinical Immunology, 2005 - Elsevier
Biliary atresia (BA) is an inflammatory cholangiopathy of infancy. A proposed mechanism
regarding the pathogenesis of BA is that of a virus-induced, immune-mediated injury to bile
ducts. The rotavirus (RRV)-induced murine model of BA was utilized to determine the
hepatic inflammatory response related to ductal obstruction and if the immune response
recapitulated human BA. One week after infection, there was a significant increase in liver
CD4+ T cells producing IFN-γ and in macrophages producing TNF-α. The intrahepatic …