[HTML][HTML] NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts
Z Zhong, TP Theruvath, RT Currin… - American journal of …, 2007 - Elsevier
ATP decreases markedly in small-for-size liver grafts. This study tested if the mitochondrial
permeability transition (MPT) underlies dysfunction of small-for-size livers. Half-size livers
were implanted into recipients of about twice the donor weight, resulting in quarter-size liver
grafts. NIM811 (5 μM), a nonimmunosuppressive MPT inhibitor was added to the storage
solutions. Mitochondrial polarization and cell death were assessed by confocal microscopy
of rhodamine 123 (Rh123) and propidium iodide (PI), respectively. After quarter-size …
permeability transition (MPT) underlies dysfunction of small-for-size livers. Half-size livers
were implanted into recipients of about twice the donor weight, resulting in quarter-size liver
grafts. NIM811 (5 μM), a nonimmunosuppressive MPT inhibitor was added to the storage
solutions. Mitochondrial polarization and cell death were assessed by confocal microscopy
of rhodamine 123 (Rh123) and propidium iodide (PI), respectively. After quarter-size …