[HTML][HTML] C5L2 is a functional receptor for acylation-stimulating protein
D Kalant, R MacLaren, W Cui, R Samanta… - Journal of Biological …, 2005 - ASBMB
C5L2 binds acylation-stimulating protein (ASP) with high affinity and is expressed in ASP-
responsive cells. Functionality of C5L2 has not yet been demonstrated. Here we show that
C5L2 is expressed in human subcutaneous and omental adipose tissue in both
preadipocytes and adipocytes. In mice, C5L2 is expressed in all adipose tissues, at levels
comparable with other tissues. Stable transfection of human C5L2 cDNA into HEK293 cells
results in ASP stimulation of triglyceride synthesis (TGS)(193±33%, 5 μm ASP, p< 0.001 …
responsive cells. Functionality of C5L2 has not yet been demonstrated. Here we show that
C5L2 is expressed in human subcutaneous and omental adipose tissue in both
preadipocytes and adipocytes. In mice, C5L2 is expressed in all adipose tissues, at levels
comparable with other tissues. Stable transfection of human C5L2 cDNA into HEK293 cells
results in ASP stimulation of triglyceride synthesis (TGS)(193±33%, 5 μm ASP, p< 0.001 …