There is a multitude of critical steps during the pathogenesis of cancer that allow cells to
acquire the ability to escape from normal controls on cell growth, to avoid programmed cell
death, and to become malignant. Here, we describe a molecular approach that can be
broadly applied to identify drivers of genomic aberrations in cancer development. In the
process, areas of genomic aberrations and genes that are dysregulated by genomic
amplification are identified by array comparative genomic hybridization (CGH) and …