Death and anti-death: tumour resistance to apoptosis
FH Igney, PH Krammer - Nature Reviews Cancer, 2002 - nature.com
FH Igney, PH Krammer
Nature Reviews Cancer, 2002•nature.comEvery cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also
render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour
resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to
cancer therapy?
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also
render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour
resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to
cancer therapy?
Abstract
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?
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