[PDF][PDF] Transient, light-induced rhythmicity in mPer-deficient mice
K Bae, DR Weaver - Journal of biological rhythms, 2007 - journals.sagepub.com
K Bae, DR Weaver
Journal of biological rhythms, 2007•journals.sagepub.comTransient, Light-Induced Rhythmicity in mPER-Deficient Mice Page 1 85 JOURNAL OF
BIOLOGICAL RHYTHMS, Vol. 22 No. 1, February 2007 85-88 DOI: 10.1177/0748730406296718
© 2007 Sage Publications The 3 mouse Period genes (mPer1, mPer2, and mPer3) have distinct
roles in regulating circadian clock function. The products of mPer1 and mPer2 appear critical
for the maintenance of circadian rhythmicity. Mice homozygous for mutations of either gene
alone have period defects and/or a gradual loss of rhythmicity in constant darkness (DD), while …
BIOLOGICAL RHYTHMS, Vol. 22 No. 1, February 2007 85-88 DOI: 10.1177/0748730406296718
© 2007 Sage Publications The 3 mouse Period genes (mPer1, mPer2, and mPer3) have distinct
roles in regulating circadian clock function. The products of mPer1 and mPer2 appear critical
for the maintenance of circadian rhythmicity. Mice homozygous for mutations of either gene
alone have period defects and/or a gradual loss of rhythmicity in constant darkness (DD), while …
Genes Disrupted Studied Restored Period Duration (h)(Days) mPer1 6 2 24.2±0.7 12.5±2.5 mPer1+ mPer3 4 3 23.0±0.2 17.0±3.5 mPer2 6 5 23.1±0.4 7.2±1.4 mPer2+ mPer3 3 3 22.3±0.4 9.3±3.3 mPer1+ mPer2 6 3 16.7±0.7 2.67±0.9 mPer1+ mPer2+ mPer3 2 1 15.25 7
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