Integrating genetic approaches into the discovery of anticancer drugs
LH Hartwell, P Szankasi, CJ Roberts, AW Murray… - Science, 1997 - science.org
The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to
understand how they define a molecular context that allows increased sensitivity to
particular compounds. Traditional genetic approaches together with the new wealth of
genomic information for both human and model organisms open up strategies by which
drugs can be profiled for their ability to selectively kill cells in a molecular context that …
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to
understand how they define a molecular context that allows increased sensitivity to
particular compounds. Traditional genetic approaches together with the new wealth of
genomic information for both human and model organisms open up strategies by which
drugs can be profiled for their ability to selectively kill cells in a molecular context that …
The discovery of anticancer drugs is now driven by the numerous molecular alterations identified in tumor cells over the past decade. To exploit these alterations, it is necessary to understand how they define a molecular context that allows increased sensitivity to particular compounds. Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors. Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context. This article outlines some of the ways that yeast genetics can be used to streamline anticancer drug discovery.
AAAS