[HTML][HTML] Transplantation of endothelial cells corrects the phenotype in hemophilia A mice
V Kumaran, D Benten, A Follenzi, B Joseph… - Journal of Thrombosis …, 2005 - Elsevier
Background: The deficiency of factor VIII, a co‐factor in the intrinsic coagulation pathway
results in hemophilia A. Although FVIII is synthesized largely in the liver, the specific liver cell
type (s) responsible for FVIII production is controversial. Objective: This study aimed to
determine the cellular origin of FVIII synthesis and release in mouse models. Methods: We
transplanted cells into the peritoneal cavity of hemophilia A knockout mice. Plasma FVIII
activity was measured using a Chromogenix assay 2–7 days after cell transplantation, and …
results in hemophilia A. Although FVIII is synthesized largely in the liver, the specific liver cell
type (s) responsible for FVIII production is controversial. Objective: This study aimed to
determine the cellular origin of FVIII synthesis and release in mouse models. Methods: We
transplanted cells into the peritoneal cavity of hemophilia A knockout mice. Plasma FVIII
activity was measured using a Chromogenix assay 2–7 days after cell transplantation, and …