Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions
RM Plenge, LA Criswell - Current opinion in rheumatology, 2008 - journals.lww.com
Current opinion in rheumatology, 2008•journals.lww.com
Additional studies are required to investigate the genetic basis of response to anti-TNF
therapy. These studies should include an unbiased search of DNA variation across the
human genome–now feasible through cost-effective genome-wide association studies–and
be conducted in large patient collections powered to detect modest effect sizes.
therapy. These studies should include an unbiased search of DNA variation across the
human genome–now feasible through cost-effective genome-wide association studies–and
be conducted in large patient collections powered to detect modest effect sizes.
Summary
Additional studies are required to investigate the genetic basis of response to anti-TNF therapy. These studies should include an unbiased search of DNA variation across the human genome–now feasible through cost-effective genome-wide association studies–and be conducted in large patient collections powered to detect modest effect sizes.
Lippincott Williams & Wilkins