Acquired autoimmune thrombocytopenia post-bone marrow transplantation for severe combined immunodeficiency

SS Ting, JB Ziegler, MR Vowels - Bone marrow transplantation, 1998 - nature.com
SS Ting, JB Ziegler, MR Vowels
Bone marrow transplantation, 1998nature.com
Children with severe combined immunodeficiency (SCID) have profoundly diminished
humoral and cellular immunity resulting in death during infancy unless immune
reconstitution occurs by bone marrow transplantation (BMT). Thrombocytopenia post-bone
marrow transplantation can be seen in relation to infection, graft-versus-host disease
(GVHD) and rarely, as an autoimmune phenomenon due to immune dysregulation. We
report two cases of severe AITP following BMT for SCID. Both cases developed large …
Abstract
Children with severe combined immunodeficiency (SCID) have profoundly diminished humoral and cellular immunity resulting in death during infancy unless immune reconstitution occurs by bone marrow transplantation (BMT). Thrombocytopenia post-bone marrow transplantation can be seen in relation to infection, graft-versus-host disease (GVHD) and rarely, as an autoimmune phenomenon due to immune dysregulation. We report two cases of severe AITP following BMT for SCID. Both cases developed large intracerebral hemorrhages from which one died. Autoimmune thrombocytopenia in this setting can be life-threatening and we recommend early and active intervention.
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