[HTML][HTML] Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter
During pancreatic development, the paired homeodomain transcription factor PAX4 is
required for the differentiation of the insulin-producing beta cells and somatostatin-
producing delta cells. To establish the position of PAX4 in the hierarchy of factors controlling
islet cell development, we examined the control of the human PAX4 gene promoter. In both
cell lines and transgenic animals, a 4.9-kilobase pair region directly upstream of the human
PAX4 gene transcriptional start site acts as a potent pancreas-specific promoter. Deletion …
required for the differentiation of the insulin-producing beta cells and somatostatin-
producing delta cells. To establish the position of PAX4 in the hierarchy of factors controlling
islet cell development, we examined the control of the human PAX4 gene promoter. In both
cell lines and transgenic animals, a 4.9-kilobase pair region directly upstream of the human
PAX4 gene transcriptional start site acts as a potent pancreas-specific promoter. Deletion …