Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
SE Bassett, B Guerra, K Brasky, E Miskovsky… - Hepatology, 2001 - journals.lww.com
Hepatitis C virus (HCV) infections were evaluated in chimpanzees that had previously
cleared HCV and were rechallenged. Animals that had previously cleared HCV infection
rapidly cleared homologous and heterologous virus upon rechallenge, indicative of a strong
protective immunity. In one animal, sterilizing immunity was observed with regard to viremia,
although viral RNA was transiently detected in the liver. Accelerated viral clearance
following rechallenge with HCV was observed in animals that had not been exposed to HCV …
cleared HCV and were rechallenged. Animals that had previously cleared HCV infection
rapidly cleared homologous and heterologous virus upon rechallenge, indicative of a strong
protective immunity. In one animal, sterilizing immunity was observed with regard to viremia,
although viral RNA was transiently detected in the liver. Accelerated viral clearance
following rechallenge with HCV was observed in animals that had not been exposed to HCV …