Impaired development of lens fibers in genetic microphthalmia, eye lens obsolescence, Elo, of the mouse

SI Oda, K Watanabe, H Fujisawa… - Experimental eye …, 1980 - Elsevier
An autosomal dominant microphthalmia (Eye lens obsolescnece, Elo) in the mouse was
examined for early pathological changes in the developing lens. The first change was
detected on day 12 of gestation, ie elongation of the central lens fibers at the basal
cytoplasm was impaired. Necrotic cells were found among the central fiber cells, these cells
never reached full maturation length and progressively degenerated thereafter. As a
consequence, the lens in the late fetal stage was small and deformed. Initial cytological …