Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition

RJ Truscott - Experimental eye research, 2009 - Elsevier
All people will be presbyopic by age 50, and we now understand something of the basis for
this condition. It turns out to be a direct consequence of two features; first the design of the
transparent lens and the way it must change shape to enable focussing by the human eye,
and second the instability of proteins over a very long time period. The incremental changes
that take place in the lens to render the central region inflexible by middle age and, as a
consequence the person presbyopic, may also promote the subsequent development of …