[HTML][HTML] Gene Structure and cDNA Sequence Identify the Beaded Filament Protein CP49 as a Highly Divergent Type I Intermediate Filament Protein (∗)

JF Hess, JT Casselman, PG FitzGerald - Journal of Biological Chemistry, 1996 - ASBMB
The fiber cell of the vertebrate ocular lens assembles a cytoskeletal structure, the beaded
filament, which contains two proteins unique to the fiber cell: CP49 (phakinin) and
CP115/CP95 (filensin). We report here the complete primary sequence and gene structure
for human CP49. These data show that CP49 is a member of the intermediate filament
family, but highly unusual in several regards. 1) CP49 primary sequence does not permit
unambiguous assignment to any existing class of intermediate filament protein, but exhibits …