Intermediate filaments and their associated proteins: multiple dynamic personalities

MK Houseweart, DW Cleveland - Current opinion in cell biology, 1998 - Elsevier
MK Houseweart, DW Cleveland
Current opinion in cell biology, 1998Elsevier
A fusion of mouse and human genetics has now proven that intermediate filaments form a
flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some
cases, the formation of this scaffold is achieved through a newly identified family of
intermediate-filament-associated proteins that form cross-bridges between intermediate
filaments and other cytoskeletal elements, including actin and microtubules.
A fusion of mouse and human genetics has now proven that intermediate filaments form a flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some cases, the formation of this scaffold is achieved through a newly identified family of intermediate-filament-associated proteins that form cross-bridges between intermediate filaments and other cytoskeletal elements, including actin and microtubules.
Elsevier