The regulation of mitotic nuclear envelope breakdown: a role for multiple lamin kinases
AP Fields, LJ Thompson - Progress in Cell Cycle Research: Volume 1, 1995 - Springer
AP Fields, LJ Thompson
Progress in Cell Cycle Research: Volume 1, 1995•SpringerThis chapter reviews the structure and function of the nuclear envelope and describes its
dynamic structural changes during cell cycle. Particular emphasis is placed on the
regulation of mitotic nuclear envelope breakdown (NEBD), the process by which the
physical barrier between cytoplasm and nucleus is dissolved to allow for cell division. The
literature suggesting the involvement of multiple protein kinases in NEBD is reviewed and
evidence is presented that multiple mitotic lamin kinases, including p34 cdc2/cyclin B kinase …
dynamic structural changes during cell cycle. Particular emphasis is placed on the
regulation of mitotic nuclear envelope breakdown (NEBD), the process by which the
physical barrier between cytoplasm and nucleus is dissolved to allow for cell division. The
literature suggesting the involvement of multiple protein kinases in NEBD is reviewed and
evidence is presented that multiple mitotic lamin kinases, including p34 cdc2/cyclin B kinase …
Abstract
This chapter reviews the structure and function of the nuclear envelope and describes its dynamic structural changes during cell cycle. Particular emphasis is placed on the regulation of mitotic nuclear envelope breakdown (NEBD), the process by which the physical barrier between cytoplasm and nucleus is dissolved to allow for cell division. The literature suggesting the involvement of multiple protein kinases in NEBD is reviewed and evidence is presented that multiple mitotic lamin kinases, including p34cdc2/cyclin B kinase and protein kinase C, play key roles in mitotic nuclear lamina disassembly. Finally, a model for regulation of mitotic nuclear lamina disassembly by multi-site phosphorylation is described.
Springer
