Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins
Background/Aims: Animal studies revealed a key role of toxic bile acids in the regulation of
hepatocytic cytokeratin (CK) expression and Mallory body (MB) formation. In this study, we
compared CK expression, phosphorylation, and ubiquitination in primary biliary cirrhosis
(PBC), chronic hepatitis C (CHC) and control livers to determine whether bile acid-induced
CK alterations are associated with cytoskeletal alterations and MB formation in a prototypic
chronic cholestatic liver disease. Methods: CK 8 and CK 18 mRNA and protein levels were …
hepatocytic cytokeratin (CK) expression and Mallory body (MB) formation. In this study, we
compared CK expression, phosphorylation, and ubiquitination in primary biliary cirrhosis
(PBC), chronic hepatitis C (CHC) and control livers to determine whether bile acid-induced
CK alterations are associated with cytoskeletal alterations and MB formation in a prototypic
chronic cholestatic liver disease. Methods: CK 8 and CK 18 mRNA and protein levels were …