Alteration in molecular structure of cytoskeleton proteins in griseofulvin-treated mouse liver: a pressure tuning infrared spectroscopy study
M Cadrin, SW French, PTT Wong - Experimental and molecular pathology, 1991 - Elsevier
Different liver diseases are associated with modifications in hepatocyte cytoskeletal
organization and formation of Mallory bodies (MBs). Since the structure of a protein is critical
for its function, we studied the changes in the molecular structure of the cytoskeletal protein
in the liver from mice fed griseofulvin (GF), which is a good animal model for studying liver
disease. Using pressure-tuning infrared spectroscopy we compared the infrared spectra of
the cytoskeletal proteins from control liver and griseofulvin treated liver. The results show …
organization and formation of Mallory bodies (MBs). Since the structure of a protein is critical
for its function, we studied the changes in the molecular structure of the cytoskeletal protein
in the liver from mice fed griseofulvin (GF), which is a good animal model for studying liver
disease. Using pressure-tuning infrared spectroscopy we compared the infrared spectra of
the cytoskeletal proteins from control liver and griseofulvin treated liver. The results show …