[HTML][HTML] CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H
DD Bloom, Z Chang, JH Fechner, W Dar… - American Journal of …, 2008 - Elsevier
Campath-1H (Alemtuzumab) is an effective immunodepletion agent used in renal
transplantation. To evaluate its influence on T lymphocytes during repletion, we analyzed
peripheral blood from Campath-1H-treated renal allograft recipients for the presence of
FOXP3+ regulatory T (Treg) cells. Flow cytometry demonstrated that CD4+ CD25+ FOXP3+
lymphocytes increased significantly within the CD4+ T-cell population, skewing Treg/Teff (T
effector) ratios for up to several years. In contrast, Treg levels in patients treated with anti …
transplantation. To evaluate its influence on T lymphocytes during repletion, we analyzed
peripheral blood from Campath-1H-treated renal allograft recipients for the presence of
FOXP3+ regulatory T (Treg) cells. Flow cytometry demonstrated that CD4+ CD25+ FOXP3+
lymphocytes increased significantly within the CD4+ T-cell population, skewing Treg/Teff (T
effector) ratios for up to several years. In contrast, Treg levels in patients treated with anti …