The cholangiopathies: disorders of biliary epithelia

KN Lazaridis, M Strazzabosco, NF LaRusso - Gastroenterology, 2004 - gastrojournal.org
The intrahepatic bile ducts comprise a complex 3-di-mensional network of conduits within
the liver lined by specialized epithelial cells called cholangiocytes. A major function of
cholangiocytes is bile formation (Figure 1). Hepatocytes, the other epithelial cell type of the
liver, produce primary or hepatic bile, which percolates through the intrahepatic bile ducts;
during this journey, bile is modified by cholangiocytes via a series of secretory and
absorptive processes that provide additional bile water (cholangiocytes secrete 40% of daily …