[HTML][HTML] T-cell-dependent fibrosis in the mdx dystrophic mouse

J Morrison, QL Lu, C Pastoret, T Partridge… - Laboratory …, 2000 - Elsevier
In Duchenne muscular dystrophy patients, the pathological hallmark of the disease, namely,
the chronic accumulation of sclerotic scar tissue in the interstitial space of skeletal muscle is
attributed to manifestation of secondary pathological processes. Such anomalous
generation of matrix protein is thought to be driven by the continuous degeneration and
regeneration of muscle both in Duchenne Muscular Dystrophy and in the mdx mouse
homolog. We examined mdx and the control strain C57bl/10 mice over a range of ages with …