STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons
(eg IFNα). STAT2 resides primarily in the cytoplasm and is tyrosine-phosphorylated after
IFNα binds to cell surface receptors. In response to tyrosine phosphorylation STAT2 rapidly
localizes to the nucleus and acquires the ability to bind specific DNA targets in association
with two other proteins, STAT1 and IFN regulatory factor-9 (IRF-9). To elucidate the
mechanisms that regulate cellular localization of STAT2, we investigated STAT2 nuclear …