[HTML][HTML] Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression
K Banki, E Hutter, E Colombo, NJ Gonchoroff… - Journal of Biological …, 1996 - ASBMB
Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose
phosphate pathway (PPP) that is responsible for the generation of NADPH to maintain
glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from reactive
oxygen intermediates (ROIs). Formation of ROIs have been implicated in certain types of
apoptotic cell death. To evaluate the role of TAL in this process, Jurkat human T cells were
permanently transfected with TAL expression vectors oriented in the sense or antisense …
phosphate pathway (PPP) that is responsible for the generation of NADPH to maintain
glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from reactive
oxygen intermediates (ROIs). Formation of ROIs have been implicated in certain types of
apoptotic cell death. To evaluate the role of TAL in this process, Jurkat human T cells were
permanently transfected with TAL expression vectors oriented in the sense or antisense …