[PDF][PDF] C/EBP and c-JUN proteins activate the proximal enhancer of the developmentally regulated a-fetoprotein gene
C Houart, J Szpirer, C Szpirer - Int. J. On. mol. J6: 1I, 1992 - researchgate.net
C Houart, J Szpirer, C Szpirer
Int. J. On. mol. J6: 1I, 1992•researchgate.netThe expression of the u.. fetoprotein(AFP) gene is developmentally regulated. Active
transcription of this gene depends on a proximal enhancer sequence located between
positions 0.203 bp and. 81 bp, upstream the initiation site. This enhancer contains several
putative binding sites for transcription factors. Bytransfection experiments, we showed that
the enhancer activity can be driven by interactions with two regulatory factors, namely C/EBP
and c-JUN.
transcription of this gene depends on a proximal enhancer sequence located between
positions 0.203 bp and. 81 bp, upstream the initiation site. This enhancer contains several
putative binding sites for transcription factors. Bytransfection experiments, we showed that
the enhancer activity can be driven by interactions with two regulatory factors, namely C/EBP
and c-JUN.
Abstract
The expression of the u.. fetoprotein(AFP) gene is developmentally regulated. Active transcription of this gene depends on a proximal enhancer sequence located between positions 0.203 bp and. 81 bp, upstream the initiation site. This enhancer contains several putative binding sites for transcription factors. Bytransfection experiments, we showed that the enhancer activity can be driven by interactions with two regulatory factors, namely C/EBP and c-JUN.
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